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Structural and Functional Biochemistry

E-mail
ddleonidas@bio.uth.gr
Webpage
http://www.bio.uth.gr/index.php?option=com_content&view=article&id=193%3Alab-bio-7&catid=52%3Areslabs&Itemid=72&lang=el
Department
Department of Biochemistry and Biotechnology
Tel.
+30 2410 565297
Research Categories
Biochemical Analysis
X-Ray Spectroscopy
Chromatographic Analysis
Immunochemistry
Enzymology
Nucleic Acids
Proteins
Physical Biochemistry
Clinical Chemistry

The Structural and Functional Biochemistry Laboratory serves the educational and research needs in the disciplines of biochemistry (intermediate metabolism, synthesis and nucleic acid metabolism, synthesis, structure and function of proteins), structural biochemistry, proteomics, structural genomics, regulation and Metabolic Control of Enzymes and the implementation of all the above in Analytical Biochemistry, Enzymology Clinical Biochemistry, Food biochemistry, Chemical Biology, structure-driven drug design and Biophysics as applied to Biochemical Sciences.

Research Activities

Control of Glycogen Metabolism.

Elucidation of the control, diversity and biological functions of deadenylases.

Structure-based design of enzyme inhibitors.

Structural basis of carbohydrate recognition by lectins.

Characterization and function of the mitochondrial steroid hormone receptors. Mechanisms of intracellular trafficking.

Molecular Modeling.

Research Projects

University of Thessaly Research Committee. "Proteomic analysis of the entomopathogeny of Pseudomonas entomophila". Grant No. 4098. PI: Μ.Κοntou.

University of Thessaly Research Committee. "Studies on function and structure of poly(A) specific ribonuclease, PARN". Grant No. 3743. PI: Nikolaos Balatsos.

Ministry of National Education and Religion Affairs Project Eraklitos IΙ: «Τranscriptomic and proteomic analysis of the most important parasite of the olive, the insect Bactrocera oleae, with emphasis on systems gender segregation and resistance to insecticides». M.Κοntou, collaborator.

University of Thessaly Research Committee. "Structure and function studies of the poly(A) specific ribonuclease PARN". Grant No.3743. PI: Nikolaos Balatsos.

University of Thessaly Research Committee. "Role of steroid hormone receptors in mitochondria functions" Grant No. 4088.14.01. PI: Α.–Μ. Psarra.

General Secretariat for Research and Technology, Joint Research Projects Greece – France (2010–2012): Human angiogenin as a molecular target for the development of new anticancer agents. PI: D.D. Leonidas.

ARISTEIA, Structure–assisted Design, Synthesis, and Evaluation of Bioactive compounds for type 2 Diabetes mellitus, PI: D.D. Leonidas.

Laboratory Infrastructure

Two Fast Protein Liquid Chromatography Systems (FPLC).

Nano-robot for protein crystallization.

Two-dimensional Electophoresis System.

ELISA plate reader.

Speed-vac.

γ-Counter.

Micro-equipment (electrophoresis, centrifuges etc).

Research Results / Products

Structure based design and biochemical evaluation of new hypoglycaemic agents.

Structure based design and assessment of new anti-inflammatory, and anti-cancer agents.

Personnel
Surname Name Profession-Position Email Phone Number
Demetres
Leonidas
Director
ddleonidas@bio.uth.gr
+30 2410 565278
Kontou
Maria
Assistant Professor
mkontou@bio.uth.gr
+30 2410 565281
Balatsos
Nikos
Assistant Professor
balatsos@bio.uth.gr
+30 2410 565261
Papadopoulos
George
Assistant Professor
geopap@bio.uth.gr
+30 2410 565249
Psarra
Anna–Maria
Assistant Professor
ampsarra@bio.uth.gr
+30 2410 565221
Skamnaki
Vasiliki
Senior Researcher
vskamnaki@bio.uth.gr
+30 2410 565281
Katsandi
Anastassia
Researcher
+30 2410 565297
Hatzileontiadou
Demetra
Researcher
+30 2410 565297
Kiritsis
Athanasios
Researcher
+30 2410 565297
Gorgogietas
Byron
Researcher
+30 2410 565297